Selection of the key earth observation sensors and platforms focusing on applications for Polar Regions in the scope of Copernicus system 2020-2030

An optimal payload selection conducted in the frame of the H2020 ONION project (id 687490) is presented based on the ability to cover the observation needs of the Copernicus system in the time period 2020–2030. Payload selection is constrained by the variables that can be measured, the power consumption, and weight of the instrument, and the required accuracy and spatial resolution (horizontal or vertical). It involved 20 measurements with observation gaps according to the user requirements that were detected in the top 10 use cases in the scope of Copernicus space infrastructure, 9 potential applied technologies, and 39 available commercial platforms. Additional Earth Observation (EO) infrastructures are proposed to reduce measurements gaps, based on a weighting system that assigned high relevance for measurements associated to Marine for Weather Forecast over Polar Regions. This study concludes with a rank and mapping of the potential technologies and the suitable commercial platforms to cover most of the requirements of the top ten use cases, analyzing the Marine for Weather Forecast, Sea Ice Monitoring, Fishing Pressure, and Agriculture and Forestry: Hydric stress as the priority use cases.Peer ReviewedPostprint (published version

Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women

In a population-based case-control study, we explored the associations between 42 polymorphisms in seven genes in this region and non-small cell lung cancer (NSCLC) risk among Caucasian (364 cases; 380 controls) and African American (95 cases; 103 controls) women. Two TERT region SNPs, rs2075786 and rs2853677, conferred an increased risk of developing NSCLC, especially among African American women, and TERT-rs2735940 was associated with a decreased risk of lung cancer among African Americans. Five of the 20 GHR polymorphisms and SEPP1-rs6413428 were associated with a marginally increased risk of NSCLC among Caucasians. Random forest analysis reinforced the importance of GHR among Caucasians and identified AMACR, TERT, and GHR among African Americans, which were also significant using gene-based risk scores. Smoking-SNP interactions were explored, and haplotypes in TERT and GHR associated with NSCLC risk were identified. The roles of TERT, GHR, AMACR and SEPP1 genes in lung carcinogenesis warrant further exploration

Zephyr: The Second Issue

This is the second issue of Zephyr, the University of New England\u27s journal of creative expression. Since 2000, Zephyr has published original drawings, paintings, photography, prose, and verse created by current and former members of the University community. Zephyr\u27s Editorial Board is made up exclusively of matriculating students.https://dune.une.edu/zephyr/1001/thumbnail.jp

Dynamics of the Globular Cluster System Associated with M49 (NGC4472): Cluster Orbital Properties and the Distribution of Dark Matter

We have measured radial velocities for 196 globular clusters (GCs) around M49, the brightest member of the Virgo Cluster. Combined with published data, they bring the total number of GCs with measured radial velocities in this galaxy to 263. Using this sample, we extract the projected kinematics of the full sample of GCs, and of the separate metal-poor and metal-rich subsamples. In agreement with previous results for the global GC kinematics based on smaller datasets, we find that the GC system as a whole exhibits a slow overall rotation that is due almost entirely to a net rotation of the metal-poor GC subsystem alone. In a spatial average, the metal-rich GCs shows essentially no rotation. We note, however, the presence of a well defined grouping of 10 metal-rich GCs that are located at opposite poles along the galaxy's major axis and which appear to be rotating at nearly 300 km/s about the minor axis. This grouping may be the relic of a past merger or accretion event. Using a Jeans-equation analysis, we show that the GC radial velocities alone point unequivocally (and independently of X-ray observations) to the need for a massive dark halo associated with M49 and the Virgo B subcluster around it. We also show that the GC system as a whole is consistent with an almost perfectly isotropic velocity ellipsoid. M49 is now the second elliptical galaxy (after M87) for which we have been able to demonstrate velocity isotropy in the globular cluster system overall, when no division based on GC color or metallicity is attempted. Thus, the data for these two galaxies lend support the general assumption of isotropy when using GC kinematics to study the dark-matter distribution in early-type galaxies. (ABRIDGED)Comment: 63 pages, 21 postscript figures. Accepted for publication in the Astrophysical Journa

'It is like a tomato stall where someone can pick what he likes': structure and practices of female sex work in Kampala, Uganda.

BACKGROUND: Effective interventions among female sex workers require a thorough knowledge of the context of local sex industries. We explore the organisation of female sex work in a low socio-economic setting in Kampala, Uganda. METHODS: We conducted a qualitative study with 101 participants selected from an epidemiological cohort of 1027 women at high risk of HIV in Kampala. Repeat in-depth life history and work practice interviews were conducted from March 2010 to June 2011. Context specific factors of female sex workers' day-to-day lives were captured. Reported themes were identified and categorised inductively. RESULTS: Of the 101 women, 58 were active self-identified sex workers operating in different locations within the area of study and nine had quit sex work. This paper focuses on these 67 women who gave information about their involvement in sex work. The majority had not gone beyond primary level of education and all had at least one child. Thirty one voluntarily disclosed that they were HIV-positive. Common sex work locations were streets/roadsides, bars and night clubs. Typically sex occurred in lodges near bars/night clubs, dark alleyways or car parking lots. Overall, women experienced sex work-related challenges at their work locations but these were more apparent in outdoor settings. These settings exposed women to violence, visibility to police, a stigmatising public as well as competition for clients, while bars provided some protection from these challenges. Older sex workers tended to prefer bars while the younger ones were mostly based on the streets. Alcohol consumption was a feature in all locations and women said it gave them courage and helped them to withstand the night chill. Condom use was determined by clients' willingness, a woman's level of sobriety or price offered. CONCLUSIONS: Sex work operates across a variety of locations in the study area in Kampala, with each presenting different strategies and challenges for those operating there. Risky practices are present in all locations although they are higher on the streets compared to other locations. Location specific interventions are required to address the complex challenges in sex work environments

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.

We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from 14 healthy controls and 14 subjects with schizophrenia. Both healthy control cINs and schizophrenia cINs were authentic, fired spontaneously, received functional excitatory inputs from host neurons, and induced GABA-mediated inhibition in host neurons in vivo. However, schizophrenia cINs had dysregulated expression of protocadherin genes, which lie within documented schizophrenia loci. Mice lacking protocadherin-α showed defective arborization and synaptic density of prefrontal cortex cINs and behavioral abnormalities. Schizophrenia cINs similarly showed defects in synaptic density and arborization that were reversed by inhibitors of protein kinase C, a downstream kinase in the protocadherin pathway. These findings reveal an intrinsic abnormality in schizophrenia cINs in the absence of any circuit-driven pathology. They also demonstrate the utility of homogenous and functional populations of a relevant neuronal subtype for probing pathogenesis mechanisms during development

Architectural optimization framework for earth-observing heterogeneous constellations : marine weather forecast case

Earth observation satellite programs are currently facing, for some applications, the need to deliver hourly revisit times, subkilometric spatial resolutions, and near-real-time data access times. These stringent requirements, combined with the consolidation of small-satellite platforms and novel distributed architecture approaches, are stressing the need to study the design of new, heterogeneous, and heavily networked satellite systems that can potentially replace or complement traditional space assets. In this context, this paper presents partial results from ONION, a research project devoted to studying distributed satellite systems and their architecting characteristics. A design-oriented framework that allows selecting optimal architectures for the given user needs is presented in this paper. The framework has been used in the study of a strategic use-case and its results are hereby presented. From an initial design space of 5586 potential architectures, the framework has been able to preselect 28 candidate designs by an exhaustive analysis of their performance and by quantifying their quality attributes. This very exploration of architectures and the characteristics of the solution space are presented in this paper along with the selected solution and the results of a detailed performance analysis.Postprint (author's final draft

Architectural optimization results for a network of earth-observing satellite nodes

Earth observation satellite programs are currently facing, for some applications, the need to deliver hourly revisit times, sub-kilometric spatial resolutions and near-real-time data access times. These stringent requirements, combined with the consolidation of small-satellite platforms and novel distributed architecture approaches, are stressing the need to study the design of new, heterogeneous and heavily networked satellite systems that can potentially replace or complement traditional space assets. In this context, this paper presents partial results from ONION, a research project devoted to study distributed satellite systems and their architecting characteristics. A design-oriented framework that allows selecting optimal architectures for a given user needs is presented in this paper. The framework has been used in the study of a strategic use-case and its results are hereby presented. From an initial design space of 5586 unique architectures, the framework has been able to pre-select 28 candidate designs by an exhaustive analysis of their performance and by quantifying their quality attributes. This very exploration of architectures and the characteristics of the solution space, are presented in this paper along with the selected solution and the results of a detailed performance analysis.Postprint (published version

Can Biomarkers Identify Women at Increased Stroke Risk? The Women's Health Initiative Hormone Trials

Objective: The Women's Health Initiative hormone trials identified a 44% increase in ischemic stroke risk with combination estrogen plus progestin and a 39% increase with estrogen alone. We undertook a case-control biomarker study to elucidate underlying mechanisms, and to potentially identify women who would be at lower or higher risk for stroke with postmenopausal hormone therapy (HT). Design: The hormone trials were randomized, double-blind, and placebo controlled. Setting: The Women's Health Initiative trials were conducted at 40 clinical centers in the United States. Participants: The trials enrolled 27,347 postmenopausal women, aged 50-79 y. Interventions: We randomized 16,608 women with intact uterus to conjugated estrogens 0.625 mg with medroxyprogesterone acetate 2.5 mg daily or placebo, and 10,739 women with prior hysterectomy to conjugated estrogens 0.625 mg daily or placebo. Outcome Measures: Stroke was ascertained during 5.6 y of follow-up in the estrogen plus progestin trial and 6.8 y of follow-up in the estrogen alone trial. Results: No baseline clinical characteristics, including gene polymorphisms, identified women for whom the stroke risk from HT was higher. Paradoxically, women with higher baseline levels of some stroke-associated biomarkers had a lower risk of stroke when assigned to estrogen plus progestin compared to placebo. For example, those with higher IL-6 were not at increased stroke risk when assigned to estrogen plus progestin (odds ratio 1.28) but were when assigned to placebo (odds ratio 3.47; p for difference = 0.02). Similar findings occurred for high baseline PAP, leukocyte count, and D-dimer. However, only an interaction of D-dimer during follow-up interaction with HT and stroke was marginally significant (p = 0.03). Conclusions: Biomarkers did not identify women at higher stroke risk with postmenopausal HT. Some biomarkers appeared to identify women at lower stroke risk with estrogen plus progestin, but these findings may be due to chance